Club Quarters Hotel Downtown, Houston 
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8.0 (3508 Reviews) Hotel
Breakfast • Restaurant • Pet friendly
Best Price Match Best Hotels in Main Street Square. Book Today!
Main Street Square Hotels & Places to Stay in Main Street Square. Find hotels in Main Street Square, Houston.
The Whitehall Houston Best Price Match
8.2 (728 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Rusk House Serviced Apartments Best Price Match
8.7 (164 Reviews) Aparthotel
Apartments • Breakfast • Restaurant
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Hyatt Regency Houston Downtown Best Price Match
8.8 (976 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Hilton Americas - Houston Best Price Match
9.0 (757 Reviews) Hotel
Breakfast • Private parking • Indoor swimming pool
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Holiday Inn Houston Downtown by IHG Best Price Match
8.1 (1117 Reviews) Hotel
Breakfast • Private parking • Shuttle service (free)
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Cambria Hotel Houston Downtown Convention Center Best Price Match
8.4 (1946 Reviews) Hotel
Breakfast • Private parking • Restaurant
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The Lancaster Hotel Best Price Match
9.4 (713 Reviews) Hotel
Breakfast • Private parking • Restaurant
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AC Hotel Houston Downtown Best Price Match
8.7 (707 Reviews) Hotel
Breakfast • 2 restaurants • Pet friendly
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Houston Towers Inn, Adults-Only, Downtown, Med Ctr, NRG Best Price Match
8.8 (36 Reviews) Guest_house
Breakfast • Free on-site parking • Outdoor swimming pool
Houston Houston Museum of Natural Science • In Main Street Square · 3.9km to center
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Embassy Suites Houston - Downtown Best Price Match
8.8 (575 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Hampton Inn Houston Downtown Best Price Match
8.6 (606 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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The District at Hogg Palace, A Wyndham Hotel Best Price Match
8.6 (571 Reviews) Aparthotel
Apartments • Private parking • Pet friendly
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C. Baldwin, Curio Collection by Hilton Best Price Match
8.1 (687 Reviews) Hotel
Breakfast • Private parking • 3 restaurants
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Hotel Zaza Houston Museum District Best Price Match
8.5 (440 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
Houston Museum District • In Main Street Square · 4.3km to center
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Hotel ICON, Autograph Collection Best Price Match
8.7 (481 Reviews) Hotel
Breakfast • Private parking • Restaurant
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Holiday Inn Express Hotel & Suites Houston-Downtown Convention Center by IHG Best Price Match
7.1 (515 Reviews) Hotel
Breakfast • Free on-site parking • Indoor swimming pool
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Homewood Suites by Hilton Houston Downtown Best Price Match
8.5 (285 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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The Laura Hotel, Houston Downtown, Autograph Collection Best Price Match
8.5 (371 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Holiday Inn Express & Suites - Houston - Downtown North by IHG Best Price Match
8.6 (337 Reviews) Hotel
Breakfast • Free on-site parking • Indoor swimming pool
Houston Downtown Aquarium • In Main Street Square · 3.6km to center
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Aloft Houston Downtown Best Price Match
7.4 (404 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Wanderstay Boutique Hotel Best Price Match
8.8 (225 Reviews) Hotel
Pet friendly • Free WiFi • Free parking
Houston Second Ward • In Main Street Square · 2.4km to center
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SpringHill Suites by Marriott Houston Downtown/Convention Center Best Price Match
8.2 (268 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Magnolia Hotel Houston, a Tribute Portfolio Hotel Best Price Match
8.5 (207 Reviews) Hotel
Breakfast • Outdoor swimming pool • Restaurant
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Tru By Hilton Houston Downtown Convention Center Best Price Match
8.5 (183 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Residence Inn Houston Downtown/Convention Center Best Price Match
8.6 (173 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Sleep Inn and Suites Downtown Houston Best Price Match
7.9 (223 Reviews) Hotel
Breakfast • Free on-site parking • Free WiFi
Houston Houston Heights • In Main Street Square · 4.2km to center
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Courtyard Houston Downtown Convention Center Best Price Match
8.2 (183 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Le Meridien Houston Downtown Best Price Match
8.2 (165 Reviews) Hotel
Breakfast • Private parking • 3 restaurants
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Home2 Suites By Hilton Houston Downtown Convention Center Best Price Match
8.7 (132 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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Courtyard by Marriott Houston Heights/I-10 Best Price Match
8.8 (126 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
Houston Houston Heights • In Main Street Square · 3.5km to center
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La Colombe d'Or Hotel Best Price Match
9.0 (73 Reviews) Hotel
Private parking • 2 swimming pools • Restaurant
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Four Seasons Hotel Houston Best Price Match
9.1 (63 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
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The Sam Houston, Tapestry Collection by Hilton Best Price Match
7.9 (88 Reviews) Hotel
Breakfast • Private parking • Restaurant
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Modern B & B Best Price Match
8.5 (137 Reviews) Bed_and_breakfast
Breakfast • Free on-site parking • Pet friendly
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Best Western Plus Downtown Inn & Suites Best Price Match
8.6 (910 Reviews) Hotel
Breakfast • Private parking • Outdoor swimming pool
Houston Fourth Ward • In Main Street Square · 1.2km to center
Best Price Match About Main Street Square Hotels with Suites on NearbyHoliday
Looking for hotels in Main Street Square? Compare top options in Houston.
NearbyHoliday features the hottest hotel deals in Main Street Square, US. In addition to the best hotels and best resorts, we have many hotels that offer full hotel suites in Main Street Square, from budget to luxury, to suit your needs as well.
Our site boasts of more than 56 hotels listed in or near Main Street Square. Whether you are going on a business trip, leisure vacation with a group, or traveling with your family or friends for summer or winter break, there is always a hotel or resort perfect for you.
From beachfront hotels and all inclusive resorts, to boutique hotels and luxury rentals, we have thousands of hotels, resorts, inns, and motels with updated prices for 2026. NearbyHoliday also lists many last minute hotels and cheap hotels from many of the top travel providers, including top hotel chains such as Radisson Hotel, OYO, Marriott, Hyatt, Hilton, MGM Resorts, & more.